Bibliometric and Visual Analysis of Research on Depression in Older Adults and Gut Microbiota Based#br#
on CiteSpace
Chen Zizhen¹, Yuan Zhiqiong¹, Zhang Xiao², Ji Siyu¹, Guo Shouxia¹, Guo Qinghua¹, Li Lijuan¹*
( 1. College of Public Health, Dali University, Dali, Yunnan 671000, China; 2. School of Public Health, Gansu University of Chinese
Medicine, Lanzhou 730000, China)
Chen Zizhen¹, Yuan Zhiqiong¹, Zhang Xiao², Ji Siyu¹, Guo Shouxia¹, Guo Qinghua¹, Li Lijuan¹. Bibliometric and Visual Analysis of Research on Depression in Older Adults and Gut Microbiota Based#br#
on CiteSpace[J]. Journal of Dali University, 2026, 11(4): 42-54.
〔1〕 WALASZEK A. Optimizing the Treatment of Late-Life De⁃
pression〔J〕. Am J Psychiatry，2024，181（1）：7-10.
〔2〕 FERRARI A J，CHARLSON F J，NORMAN R E，et al. Bur⁃
den of Depressive Disorders by Country，Sex，Age，and
Year：Findings from the Global Burden of Disease Study
2010〔J〕. PLoS Med，2013，10（11）：e1001547.
〔3〕 吕朋朋，杨风，罗光强，等.老年抑郁症和心血管疾病关
系的研究进展〔J〕. 中国医学科学院学报，2022，44（6）：
1089-1094.
〔4〕 ZENEBE Y，AKELE B，W/SELASSIE M，et al. Prevalence
and Determinants of Depression among Old Age：A Systematic
Review and Meta-Analysis〔J〕. Ann Gen Psychiatry，
2021，20（1）：55.
〔5〕 VYAS C M，OKEREKE O I. Late-Life Depression：A Nar⁃
rative Review on Risk Factors and Prevention〔J〕. Harv
Rev Psychiatry，2020，28（2）：72-99.
〔6〕 ARSENAULT-LAPIERRE G，KIM C，TURECKI G. Psy⁃
chiatric Diagnoses in 3 275 Suicides：A Meta-Analysis〔J〕.
BMC Psychiatry，2004，4：37.
〔7〕 HERRMAN H，PATEL V，KIELING C，et al. Time for United
Action on Depression：A Lancet-World Psychiatric Association
Commission〔J〕. Lancet，2022，399（10328）：957-1022.
〔8〕 DEVITA M，DE SALVO R，RAVELLI A，et al. Recognizing
Depression in the Elderly：Practical Guidance and Chal⁃
lenges for Clinical Management〔J〕. Neuropsychiatr Dis
Treat，2022，18：2867-2880.
〔9〕 MANSOUR R，TSAMAKIS K，RIZOS E，et al. Late-Life
Depression in People from Ethnic Minority Backgrounds：
Differences in Presentation and Management〔J〕. J Affect
Disord，2020，264：340-347.
〔10〕 CRYAN J F，O'RIORDAN K J，COWAN C S M，et al. The
Microbiota-Gut-Brain Axis〔J〕. Physiol Rev，2019，99
（4）：1877-2013.
〔11〕 MCVEY NEUFELD K A，BIENENSTOCK J，BHARWANI
A，et al. Oral Selective Serotonin Reuptake Inhibitors Acti⁃
vate Vagus Nerve Dependent Gut-Brain Signalling〔J〕.
Sci Rep，2019，9（1）：14290.
〔12〕 LIU S H，GUO R J，LIU F，et al. Gut Microbiota Regulates
Depression-Like Behavior in Rats through the Neuroendocrine-
Immune-Mitochondrial Pathway〔J〕. Neuropsychiatr Dis
Treat，2020，16：859-869.
〔13〕 VALLES-COLOMER M，FALONY G，DARZI Y，et al.
The Neuroactive Potential of the Human Gut Microbiota in
Quality of Life and Depression〔J〕. Nat Microbiol，2019，4
（4）：623-632.
〔14〕 YANG Z L，LI J J，GUI X H，et al. Updated Review of Re⁃
search on the Gut Microbiota and Their Relation to De⁃
pression in Animals and Human Beings〔J〕. Mol Psychia⁃
try，2020，25（11）：2759-2772.
〔15〕 MARX W，LANE M，HOCKEY M，et al. Diet and Depres⁃
sion：Exploring the Biological Mechanisms of Action〔J〕.
Mol Psychiatry，2021，26（1）：134-150.
〔16〕 HERSELMAN M F，BAILEY S，BOBROVSKAYA L. The
Effects of Stress and Diet on the“ Brain-Gut” and“ Gut-
Brain” Pathways in Animal Models of Stress and Depres⁃
sion〔J〕. Int J Mol Sci，2022，23（4）：2013.
〔17〕 WEI K，LIN S H，YANG J J，et al. Dietary Habits and De⁃
pression in Community-Dwelling Chinese Older Adults：
Cross-Sectional Analysis of the Moderating Role of Physi⁃
cal Exercise〔J〕. Nutrients，2024，16（5）：740.
〔18〕 GHOSH T S，SHANAHAN F，O’TOOLE P W. The Gut
Microbiome as a Modulator of Healthy Ageing〔J〕. Nat
Rev Gastroenterol Hepatol，2022，19（9）：565-584.
〔19〕 MARGOLIS K G ，CRYAN J F ，MAYER E A. The
Microbiota-Gut-Brain Axis：From Motility to Mood〔J〕.
Gastroenterology，2021，160（5）：1486-1501.
〔20〕 CHEN J J，HE S R，FANG L，et al. Age-Specific Differen⁃
tial Changes on Gut Microbiota Composition in Patients
with Major Depressive Disorder〔J〕. Aging，2020，12（3）：
2764-2776.
〔21〕 MIYAHO K，SANADA K，KUROKAWA S，et al. The Poten⁃
tial Impact of Age on Gut Microbiota in Patients with Major De⁃
pressive Disorder：A Secondary Analysis of the Prospective Ob⁃
servational Study〔J〕. J Pers Med，2022，12（11）：1827.
〔22〕 CHEN Y，LE D S，XU J X，et al. Gut Microbiota Dysbiosis
and Inflammation Dysfunction in Late-Life Depression：
An Observational Cross-Sectional Analysis〔J〕. Neuropsy⁃
chiatr Dis Treat，2024，20：399-414.
〔23〕 TSAI C F，CHUANG C H，WANG Y P，et al. Differences
in Gut Microbiota Correlate with Symptoms and Regional
Brain Volumes in Patients with Late-Life Depression〔J〕.
Front Aging Neurosci，2022，14：885393.
〔24〕 WU Y L，XU J，RONG X Y，et al. Gut Microbiota Altera⁃
tions and Health Status in Aging Adults：From Correlation
to Causation〔J〕. Aging Med，2021，4（3）：206-213.
〔25〕 ZHU X Q，HU J Q，DENG S H，et al. Bibliometric and Vi⁃
sual Analysis of Research on the Links between the Gut
Microbiota and Depression from 1999 to 2019〔J〕. Front
Psychiatry，2021，11：587670.
〔26〕 HUA N，TAN X M，HE Y Q，et al. Medical Decision-
Making for Adolescents with Depression：A Bibliometric
Study and Visualization Analysis via CiteSpace〔J〕. Int J
Ment Health Nurs，2023，32（2）：365-377.
〔27〕 WANG Q，YANG K L，ZHANG Z，et al. Characterization
of Global Research Trends and Prospects on Single-Cell
Sequencing Technology：Bibliometric Analysis〔J〕. J Med
Internet Res，2021，23（8）：e25789.
〔28〕 SYNNESTVEDT M B ，CHEN C M ，HOLMES J H.
CiteSpace Ⅱ：Visualization and Knowledge Discovery in
Bibliographic Databases〔J〕. AMIA Annu Symp Proc，
2005，2005：724-728.
〔29〕 LAN Z W，TANG X Q，LU M，et al. The Role of Short-
Chain Fatty Acids in Central Nervous System Diseases：A
Bibliometric and Visualized Analysis with Future Direc⁃
tions〔J〕. Heliyon，2024，10（4）：e26377.
〔30〕 WANG H，LONG T L，YOU J，et al. Bibliometric Visualization
Analysis of Microbiome-Gut-Brain Axis from
2004 to 2020〔J〕. Med Sci Monit，2022，28：e936037.
〔31〕 WANG H X，WANG Y P. Gut Microbiota-Brain Axis〔J〕.
Chin Med J，2016，129（19）：2373-2380.
〔32〕 RAHMAN M，FUKUI T. BIOMEDICAL RESEARCH
PRODUCTIVITY：Factors across the Countries〔J〕. Int J
Technol Assess Health Care，2003，19（1）：249-252.
〔33〕 ZYOUD S H，SMALE S，WARING W S，et al. Global Re⁃
search Trends in the Microbiome Related to Irritable
Bowel Syndrome：A Bibliometric and Visualized Study〔J〕.
World J Gastroenterol，2021，27（13）：1341-1353.
〔34〕 HADRICH D. New EU Projects Delivering Human Micro⁃
biome Applications〔J〕. Future Sci OA，2020，6（6）：
FSO474.
〔35〕 CRYAN J F，DINAN T G. Mind-Altering Microorganisms：
The Impact of the Gut Microbiota on Brain and Behaviour
〔J〕. Nat Rev Neurosci，2012，13（10）：701-712.
〔36〕 BRAVO J A，FORSYTHE P，CHEW M V，et al. Ingestion
of Lactobacillus strain Regulates Emotional Behavior and
Central GABA Receptor Expression in a Mouse via the
Vagus Nerve〔J〕. Proc Natl Acad Sci USA，2011，108
（38）：16050-16055.
〔37〕 MCGUINNESS A J，DAVIS J A，DAWSON S L，et al. A
Systematic Review of Gut Microbiota Composition in Ob⁃
servational Studies of Major Depressive Disorder，Bipolar
Disorder and Schizophrenia〔J〕. Mol Psychiatry，2022，27
（4）：1920-1935.
〔38〕 BAI J B，ELDRIDGE R，HOUSER M，et al. Multi-Omics
Analysis of the Gut Microbiome and Metabolites Associated
with the Psychoneurological Symptom Cluster in Children
with Cancer Receiving Chemotherapy〔J〕. J Transl Med，
2024，22（1）：256.
〔39〕 KOLOBARIC A，ANDREESCU C，JAŠAREVIĆ E，et al.
Gut Microbiome Predicts Cognitive Function and Depres⁃
sive Symptoms in Late Life〔J〕. Mol Psychiatry，2024，29
（10）：3064-3075.
〔40〕 YANG J J，DENG Y H，CAI Y Z，et al. Mapping Trends
and Hotspot Regarding Gastrointestinal Microbiome and
Neuroscience：A Bibliometric Analysis of Global Research
（2002-2022）〔J〕. Front Neurosci，2022，16：1048565.
〔41〕 ZHENG P，ZENG B，ZHOU C，et al. Gut Microbiome Re⁃
modeling Induces Depressive-Like Behaviors through a
Pathway Mediated by the Host's Metabolism〔J〕. Mol Psy⁃
chiatry，2016，21（6）：786-796.
〔42〕 KELLY J R，BORRE Y，O' BRIEN C，et al. Transferring
the Blues：Depression-Associated Gut Microbiota Induces
Neurobehavioural Changes in the Rat〔J〕. J Psychiatr Res，
2016，82：109-118.
〔43〕 CHEUNG S G，GOLDENTHAL A R，UHLEMANN A C，
et al. Systematic Review of Gut Microbiota and Major De⁃
pression〔J〕. Front Psychiatry，2019，10：34.
〔44〕 NIKOLOVA V L，SMITH M R B，HALL L J，et al. Pertur⁃
bations in Gut Microbiota Composition in Psychiatric Dis⁃
orders：A Review and Meta-Analysis〔J〕. JAMA Psychia⁃
try，2021，78（12）：1343-1354.
〔45〕 LEE J，VENNA V R，DURGAN D J，et al. Young versus
Aged Microbiota Transplants to Germ-Free Mice：In⁃
creased Short-Chain Fatty Acids and Improved Cognitive
Performance〔J〕. Gut Microbes，2020，12（1）：1814107.
〔46〕 NAGY-SZAKAL D，WILLIAMS B L，MISHRA N，et al.
Fecal Metagenomic Profiles in Subgroups of Patients with
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome〔J〕.
Microbiome，2017，5（1）：44.
〔47〕 ROOMRUANGWONG C，KANCHANATAWAN B，SIRIVICHAYAKUL
S，et al. IgA/IgM Responses to Gram-
Negative Bacteria Are Not Associated with Perinatal De⁃
pression，but with Physio-Somatic Symptoms and Activa⁃
tion of the Tryptophan Catabolite Pathway at the End of
Term and Postnatal Anxiety〔J〕. CNS Neurol Disord Drug
Targets，2017，16（4）：472-483.
〔48〕 RATINER K，CIOCAN D，ABDEEN S K，et al. Utilization
of the Microbiome in Personalized Medicine〔J〕. Nat Rev
Microbiol，2024，22（5）：291-308.
〔49〕 BHARWANI A，SZAMOSI J C，TAYLOR V H，et al.
Changes in the Gut Microbiome Associated with Infliximab
in Patients with Bipolar Disorder〔J〕. Brain Behav，
2021，11（8）：e2259.
〔50〕 GAO H，HE C W，XIN S Z，et al. Current Insights into the
Use of Probiotics and Fatty Acids in Alleviating Depres⁃
sion〔J〕. Microorganisms，2023，11（8）：2018.
〔51〕 ZHANG Q，CHEN B，ZHANG J H，et al. Effect of Prebiotics，
Probiotics，Synbiotics on Depression：Results from a
Meta-Analysis〔J〕. BMC Psychiatry，2023，23（1）：477.
〔52〕 TUNG T H，CHEN Y C，LIN Y T，et al. N-3 PUFA Ame⁃
liorates the Gut Microbiota，Bile Acid Profiles，and Neuro⁃
psychiatric Behaviours in a Rat Model of Geriatric Depres⁃
sion〔J〕. Biomedicines，2022，10（7）：1594.
〔53〕 HUANG H S ，LIN Y E ，PANYOD S ，et al. Anti-
Depressive-Like and Cognitive Impairment Alleviation Ef⁃
fects of Gastrodia elata Blume Water Extract Is Related to
Gut Microbiome Remodeling in ApoE （-/-） Mice Ex⁃
posed to Unpredictable Chronic Mild Stress〔J〕. J Ethno⁃
pharmacol，2023，302（Pt B）：115872.
〔54〕 COOKE N C A，BALA A，ALLARD J P，et al. The Safety
and Efficacy of Fecal Microbiota Transplantation in a
Population with Bipolar Disorder during Depressive Epi⁃
sodes：Study Protocol for a Pilot Randomized Controlled
Tria〔l J〕. Pilot Feasibility Stud，2021，7（1）：142.
〔55〕 STANISLAWSKI M A ，STAMPER C E ，STEARNSYODER
K A，et al. Characterization of the Gut Microbiota
among Veterans with Unique Military-Related Exposures
and High Prevalence of Chronic Health Conditions：A
United States-Veteran Microbiome Project （US-VMP）
Study〔J〕. Brain Behav Immun Health，2021，18：100346.
〔56〕 RHEE S J，KIM H，LEE Y，et al. The Association between
Serum Microbial DNA Composition and Symptoms of De⁃
pression and Anxiety in Mood Disorders〔J〕. Sci Rep，
2021，11（1）：13987.
〔57〕 MANOSSO L M，LIN J，CARLESSI A S，et al. Sex-
Related Patterns of the Gut-Microbiota-Brain Axis in the
Neuropsychiatric Conditions〔J〕. Brain Res Bull，2021，
171：196-208.
〔58〕 WANG Y P，ZHOU J J，YE J B，et al. Multi-Omics Re⁃
veal Microbial Determinants Impacting the Treatment Out⁃
come of Antidepressants in Major Depressive Disor⁃
der〔J〕. Microbiome，2023，11（1）：195.
〔59〕 RADJABZADEH D，BOSCH J A，UITTERLINDEN A G，
et al. Gut Microbiome-Wide Association Study of Depres⁃
sive Symptoms〔J〕. Nat Commun，2022，13（1）：7128.
〔60〕 FOSTER J A，TRIVEDI M H. The Gut-Brain Axis in De⁃
pression：Are Multi-Omics Showing the Way?〔J〕. Cell
Rep Med，2024，5（9）：101741.
〔61〕 SCHAUB A C，SCHNEIDER E，VAZQUEZ-CASTELLANOS
J F，et al. Clinical，Gut Microbial and Neural Effects of a
Probiotic Add-on Therapy in Depressed Patients：A Ran⁃
domized Controlled Trial〔J〕. Transl Psychiatry，2022，12
（1）：227.
〔62〕 NIKOLOVA V L，CLEARE A J，YOUNG A H，et al. Ac⁃
ceptability，Tolerability，and Estimates of Putative Treat⁃
ment Effects of Probiotics as Adjunctive Treatment in Pa⁃
tients with Depression：A Randomized Clinical Trial〔J〕.
JAMA Psychiatry，2023，80（8）：842-847.
